© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

According to the Law of Non–Contradiction, no statement and its negation are jointly true. According to many critics, Christians cannot serve both the orthodox faith and the Law of Non–Contradiction: if they hold to the one they must despise the other. And according to an impressive number of these critics, Christians who cling to the traditional doctrine of the Trinity must despise the Law of Non–Contradiction. Augustine's statement of this doctrine poses the problem as poignantly as any.

Students in the humanities have found Antigone intriguing ever since she was cast as the focal character in Sophocles's much contemplated tragedy. Antigone is enigmatic, to be sure; until comparatively recently, most interpretations of her focused on her role in the context of the tragic series of events unfolding in the play. These accounts relied heavily on her portrayal by Hegel, as representing the prepolitical ties of kinship coming into conflict with the ascending authority of the state.Richer life was breathed (...) into the 2,400-year-old play, however, by Jacques Lacan in his 1960 lecture "The Essence of Tragedy."1 As a result, over the past several decades an intense interest has developed in the persona of... (shrink)

This report on research in progress lists ratings of journals useful for business & society scholars for publishing. Ratings by an expert panel of such scholars are presented. Included are journals focused largely on this and closely related fields, and also those that reach a wider audience involved with management studies.

Liberal democracy is today under unprecedented attack from both the left and the right. Offering a fresh and penetrating examination of how Leo Strauss understood the emergence of liberal democracy and what is necessary to sustain and elevate it, Leo Strauss on Modern Democracy, Technology, and Liberal Education explores Strauss' view of the intimate (and troubling) relation between the philosophic promotion of liberal democracy and the turn to the modern scientific-technological project of the 'conquest of nature'. Timothy W. Burns (...) explicates the political reasoning behind Strauss' recommendation of reminders of genuine political greatness within democracy over and against the failure of nihilistic youth to recognize it. Elucidating what Strauss envisaged by a liberally-educated sub-political or cultural-level aristocracy--one that could elevate and sustain liberal democracy--and the roles that both philosophy and divine-law traditions should have in that education, Burns also lays out Strauss' frequent (though often tacit) engagement with the thought of Heidegger on these issues." -- Page 4 of cover. (shrink)

Throughout much of his long life, Kenneth Burke was recognized as a leading American intellectual, perhaps the most significant critic writing in English since Coleridge. From about 1950 on, rhetoricians in both English and speech began to see him as a major contributor to the New Rhetoric. But despite Burke's own claims to be writing philosophy and some notice from reviewers and critics that his work was philosophically significant, Timothy W. Crusius is the first to access his work as (...) philosophy. Crusius traces Burke's commitment and contributions to philosophy prior to 1945, from Counter-Statement through The Philosophy of Literary Form. While Burke might have been a late modernist thinker, Crusius shows that Burke actually starts from a position closely akin to such postmodern figures as Michel Foucault and Richard Rorty. Crusius then examines Burke's work from A Grammar of Motives up to his last published essays, drawing most heavily on A Rhetoric of Motives, The Rhetoric of Religion, and uncollected essays from the 1970s. This part concerns Burke's contributions to human activities always closely associated with rhetoric-hermeneutics, dialectic, and praxis. Burke's highly developed notion of our species as the "symbol-using animal," argues Crusius, draws together the various strands of his later philosophy—his concern with interpretation, with dialectic and dialogue, with a praxis devoted to awareness and control of the self-deceiving and potentially self-destructive motives inherent in language itself. (shrink)

This study reassesses the concept of the Anthropocene as a new geological age as it is influencing contemporary debates in social theory. As a unit of geological time whose changes are allegedly caused, directly and indirectly, by human beings, this scientific concept challenges the existing constructions of theoretical binaries, such as nature/culture, environment/society, objectivity/subjectivity or happenstance/design, in social theory. The analysis suggests many understandings of the Anthropocene in social theory are politicized over-interpretations of natural events, and these moves appear to (...) be developing moral rhetorics of, and operational plans for, managing the Anthropocene to create specific outcomes for those who are the managers as well as the managed. The fact that human beings do not, in fact, have this measure of technical control is ignored by advocates of Anthropocenarian politics to advance their policy agendas. (shrink)

The act of mindreading has been recognized to have great moral and epistemic value. Unfortunately, psychological research has shown that we are naturally inaccurate at mindreading, which should worry us quite a bit. It has also been shown that when motivated to mindread well, subjects become more accurate. In this paper I argue that some kinds of artwork—specifically, those utilizing dramatic irony—can educate us as to how valuable accurate mindreading is and motivate us to try to mindread well. The primary (...) example I discuss is Alfred Hitchcock’s film Notorious. (shrink)

St. Paul writes, “whatever you do, do everything for the glory of God (1 Corinthians 10: 31 NABRE).” This essay employs the work of St. Thomas Aquinas and the recent philosophical work of Daniel Johnson (2020) on this command to investigate a series of questions that the command raises. What is glory? How does one properly act for glory and for the glory of another? How is it possible to do everything for the glory of God? I begin with Aquinas’ (...) account of glory and the pursuit of glory for God’s glory and Aquinas’s answers to some of the above questions that can be drawn from his discussion in De Malo. I defend Aquinas against criticisms from Daniel Johnson and present his own interpretation of the command. I advance the discussion through adding two additional interpretations that do not rely on a controversial assumption Johnson makes. Next, I address the puzzle of how we can intend everything for the glory of God using Aquinas’s three-fold account of intention. Finally, I discuss the relation between charity and the desire for God’s glory and how regular, actual intentions of one’s actions for the glory of God increases charity. (shrink)

_Brill's Companion to Leo Strauss’ Writings on Classical Political Thought_ offers clear, accessible essays to assist a new generation of readers in their introduction to Strauss’ writings on the ancients, and to deepen the understanding of those familiar with his work.

A great many philosophers and theologians have recently maintained that we ought to adopt the following interpretation of the Christian Church’s proclamation that Jesus Christ is perfectly human and perfectly divine:(1) The one person Jesus Christ has every essential property of the kind humanity and every essential property of the kind divinity,where F is an essential property of a kind k just in case there is no possible world in which something belongs to k yet lacks F. I argue that (...) these writers need to do much more work if they are to convince us that their view is rationally preferable to rival interpretations of traditional Christology. To be specific, they must try to persuade us that (1) plays an indispensable rôle in our best available explanation of how Christ’s life, death, and resurrection atone for our sins. (shrink)

In Recovering the Ancient View of Founding, Timothy Caspar defends the influential political thinker Cicero and his philosophical dialogue De Legibus. Cicero and De Legibus have often been criticized as eclectic and mismatched parts stitched together. However, through close reading and robust scholarship, Caspar illuminates how De Legibus was in fact a unified and original work, and an important development of classical political philosophy.

Robert Roberts and Jay Wood criticize St Thomas Aquinas’s distinction between intellectual and moral virtues. They offer three objections to this distinction. They object that intellectual virtues depend on the will in ways that undermine the distinction, that the subject of intellectual virtues is not an intellectual faculty but a whole person, and that some intellectual virtues require that the will act intellectually. They hold that each of these is sufficient to undermine the distinction. I defend Aquinas’s distinction and respond (...) to each of their objections. I then briefly motivate why this is a distinction worth keeping. (shrink)

A collection of essays by Timothy W. Luke discussing social and political issues related to ecology, environmentalism, ecocriticism, global climate change, and the Anthropocene.

There has been a recent surge of interest in the moral philosophy of Iris Murdoch. One issue that has arisen is whether her view advocates a form of moral perception. In this paper I argue that her view does indeed advocate for a form of moral perception—what I call weak moral perception. In the process of moral reasoning weak moral perception plays a preparatory role for moral judgment, which means that moral judgment isn’t simply a matter of seeing what action (...) to perform, but that the right kind of perception is crucial to being able to make good moral decisions. One aspect of Murdoch’s account that has aroused special interest is her suggestion that the right kind of perception relies on the agent’s being in a state of love. I give what I think is the correct account of Murdochian love, which then allows me to defend her view against red herring-type objections raised recently by David Velleman and Charles Starkey. (shrink)

We describe a novel affect-inspired mechanism to improve the performance of computational systems operating in dynamic environments. In particular, we designed a mechanism that is based on aspects of the fear response in humans to dynamically reallocate operating system-level central processing unit (CPU) resources to processes as they are needed to deal with time-critical events. We evaluated this system in the MINIX® and Linux® operating systems and in three different testing environments (two simulated, one live). We found the affect-based system (...) was not only able to react more rapidly to time-critical events as intended, but since the dynamic processes for handling these events did not need to use significant CPU when they were not in time-critical situations, our simulated unmanned aerial vehicle (UAV) was able to perform even non-emergency tasks at a higher level of efficiency and reactivity than was possible in the standard implementation. (shrink)

Considerable effort has been devoted over the last fifteen years by faculty and administrators in numerous colleges and universities, and by organizations such as the Aspen Institute and Teagle Foundation, to enhancing business education through broad infusion of the perspectives and content of the liberal arts. The emphasis has been on integration of the social sciences and especially the humanities. The author—a natural scientist—recounts a seminal experience that motivated him to work more intensively on this initiative with his colleagues across (...) academic divisions at his home institution and beyond. He also argues for more engagement by natural science faculty in this process and examines the transdisciplinary re-visioning required to transform business teaching, learning, and practice into a new paradigm consistent with ecological reality. (shrink)

Previous research has linked the concept of number and other ordinal series to space via a spatially oriented mental number line. In addition, it has been shown that in visual scene recognition and production, speakers of a language with a left-to-right orthography respond faster to and tend to draw images in which the agent of an action is located to the left of the patient. In this study, we aim to bridge these two lines of research by employing a novel (...) method that measures the spatial bias produced by transitive sentences that use a wide variety of abstract and concrete verbs. Across four experiments, participants read sentences and then responded to probe words appearing on either the left or right sides of the screen. Probe words consisted of agents, patients, other words in the sentence, or newly encountered words. We found consistent lateral biases to responding to agents and patients, which appears to be independent of order of mention in the sentence but which does reflect a correspondence between position in the sentence and role in the causal sequence of the action. Our results also show that this spatial bias is driven by the use of the hands in two different ways: The left hand shows a greater sensitivity to the spatial effect than the right hand, and vocal responses produce no spatial effect. (shrink)

Feminist standpoint epistemology suggests that women are cognitively privileged, since gender-specific forms of oppression produce insights systematically denied to men. Yet if many forms of oppression exist, what happens when they overlap? Some reject such theories as irredeemably essentialist, triumphalist, and relativist, but I argue that their original versions in Hegel and Lukács as supplemented by Sabina Lovibond generate both the strongest arguments for standpoint theories and a way through their deepest difficulties.

The primary transcripts, pre‐mRNAs, of almost all protein‐coding genes in higher eukaryotes contain multiple non‐coding intervening sequences, introns, which must be precisely removed to yield translatable mRNAs. The process of intron excision, splicing, takes place in a massive ribonucleoprotein complex known as the spliceosome. Extensive studies, both genetic and biochemical, in a variety of systems have revealed that essential components of the spliceosome include five small RNAs–U1, U2, U4, U5 and U6, each of which functions as a RNA, protein complex (...) called an snRNP (small nuclear ribonucleoprotein). In addition to snRNPs, splicing requires many non‐snRNP protein factors, the exact nature and number of which has been unclear. Technical advances, including new affinity purification methods and improved mass spectrometry techniques, coupled with the completion of many genome sequences, have now permitted a number of proteomic analyses of purified spliceosomes. These studies, recently reviewed by Jurica and Moore,1 reveal that the spliceosome is composed of as many as 300 distinct proteins and five RNAs, making it among the most complex macromolecular machines known. BioEssays 25:1147–1149, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Recent results from two different studies show evidence of strong emotional engagement in moral dilemmas that require personal involvement or ethical problems that involve significant inter-personal issues. This empirical evidence for a connection between emotional engagement and moral or ethical choices is interesting because it is related to a fundamental survival mechanism rooted in human evolution. The results lead one to question when and how emotional engagement might occur in a professional ethical situation. However, the studies employed static dilemmas or (...) problems that offered only two choices whose outcome was certain or nearly so, whereas actual problems in professional ethics are dynamic and typically involve considerable uncertainty. The circumstances of three example cases suggest that increasing personal involvement and uncertainty could have been perceived as changes, threats, or opportunities and could therefore have elicited an emotional response as a way to ensure the reputation, integrity or success of oneself or a group to which one belongs. Such emotional engagement is only suggested and more studies and experiments are required to better characterize the role of emotional engagement in professional ethics. (shrink)

SOME PHILOSOPHERS RESORT TO RELATIVE IDENTITY IN ORDER TO DEFEND THE CHRISTIAN DOCTRINE OF THE TRINITY AGAINST ACCUSATIONS OF INCOHERENCE: THEY CLAIM THAT FATHER, SON, AND HOLY SPIRIT ARE NUMERICALLY THE SAME DEITY BUT ALSO NUMERICALLY DISTINCT PERSONS. I ARGUE THAT THEIR CLAIM IS EITHER INCOHERENT OR IMPOSSIBLE TO MOTIVATE. I ALSO ARGUE THAT THE SOCIAL INTERPRETATION OF THE TRINITY, ACCORDING TO WHICH FATHER, SON, AND HOLY SPIRIT ARE DISTINCT "SIMPLICITER", IS NOT OBVIOUSLY UNORTHODOX.

ExcerptWhat factors lead to any war being fought in a particular manner? How and why do those factors become institutionalized, or abandoned, as prime forms of war for typifying other armed conflicts in changing world orders? When and why do the prevailing parameters of world order shape the conduct of war? Questions about the forms of war became highly salient in 1945 when, by virtue of the United Nations Charter, “the peoples of the United Nations determined” to organize stronger institutions (...) for global governance with an elaborate apparatus of multiple functional agencies “to save succeeding generations from the scourge of war” by establishing conditions “under which justice and respect for the obligations arising from treaties and other sources of international law can be maintained” as well as to “promote social progress and better standards of life in larger freedom.”1. (shrink)